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Keratin-rich granulomas composed of multinucleated giant cells, a subtype of TREM2-expressing tumor-associated macrophages, are a biomarker of good prognosis in patients with head and neck squamous cell carcinoma.

Research Articles

By combining potent targeting of ALK oncoproteins and resistant mutants with brain penetrance and selectivity for ALK over TRK, the ALK inhibitor NVL-655 addresses key limitations of approved ALK inhibitors.

MYC(N) suppression and NFκB activation, the latter triggered by both tumor cell–intrinsic and –extrinsic factors, mediate cellular persistence in high-risk neuroblastoma and reveal new therapeutic approaches to prevent relapse.

Fc-enhanced anti-CTLA-4 leverages novel FcγR-dependent mechanisms to potentiate antitumor immunity and overcomes limitations of conventional anti-CTLA-4, effectively treating poorly immunogenic and refractory cancers.

EZH2 inhibitors dramatically enhance the effects of RAS pathway inhibitors by cooperatively suppressing the WNT pathway, thereby driving differentiation and enhancing apoptosis and tumor regression of colorectal cancer.

ROPN1 is a highly expressed intracellular antigen in triple-negative breast cancer, and a T-cell receptor targeting ROPN1 enables sensitive and selective cancer cell recognition, supporting use as a safe and potent T-cell therapy.

The kinases MARK2 and MARK3 are identified as requirements for the function of the YAP and TAZ oncogenes, thus providing a druggable vulnerability in Hippo-dysregulated carcinomas and sarcomas.

Neuronal pentraxin 1 (NPTX1) is identified as a therapeutically druggable driver of pancreatic cancer metastatic colonization through its action on the receptor AMIGO2, which promotes HIF-1α nuclear retention and hypoxic growth.

TET2 loss of function drives overexpression of the lncRNA MALAT1 in terminally differentiated myeloid cells, which is both necessary and sufficient for sustained inflammation that drives oncogenesis in myeloid neoplasms.

Aneuploid cells adapt to transcriptional and proteotoxic stress by enhancing RNA and protein degradation pathways, making them more sensitive to disruptions in these processes and presenting potential therapeutic targets.

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