Abstract
Major finding: E3 ligase-defective BRCA1 suppresses cancer to the same degree as wild-type BRCA1.
Strategy: Use of Brca1-mutant mouse models identified determinants of BRCA1 tumor suppression.
Impact: The BRCT repeats may be critical for tumor suppression and therapeutic intervention.
This content is only available via PDF.
©2011 American Association for Cancer Research.
2011
RSS Feeds