Abstract
Major finding: The E3 ubiquitin ligase Mule specifically targets HDAC2 for degradation.
Mechanism: Accumulation of HDAC2 blocks p53 acetylation and p53-dependent apoptosis.
Impact: Deregulation of Mule expression in cancer cells may affect the response to HDAC inhibitors.
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©2011 American Association for Cancer Research.
2011
