Vascular anomalies affect half of people with PTEN hamartoma tumor syndrome (PHTS), often appearing in early childhood. Castillo and colleagues identified the somatic disomy of the mutant copy of the PTEN gene in endothelial cells as a cause of vascular anomalies in patients with PHTS. The authors created a novel mouse model of these vascular anomalies in PHTS and demonstrated the therapeutic efficacy of PI3K signaling inhibitors. Off-label treatment with rapamycin reduced vascular overgrowth and abrogated lesion-associated pain of patients with PHTS.

See article, p. 1350.

Shiels and colleagues reported that fourteen cancer types had incidence rates that increased in the U.S. during 2010 to 2019 in at least one early-onset age group (i.e., 15–29, 30–39, 40–49-year-olds). Nine of these cancer types also increased in at least one older-onset age group (i.e., 50–59, 60–69, 70–79), including female breast, colorectal, kidney, testicular, uterine, and pancreatic cancers, as well as several...

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