The American Association for Cancer Research (AACR) NextGen Stars program recognizes and supports visionary early-career scientists pushing the boundaries of cancer research. In this set of commentaries, the 2024 NextGen Stars discuss the challenges and open questions related to their specific area of research that they find most interesting and important to address as they move forward in their careers.
Israel Cañadas1
In the ever-evolving landscape of cancer immunotherapy, the challenges posed by immune evasion and the immunosuppressive tumor microenvironment (TME) have emerged as formidable barriers to success. As we explore deeper into the complexities of these mechanisms, deciphering the mysteries of immunologically “cold” tumors is key to enhance immunotherapy efficacy. These tumors, characterized by the lack of infiltrating immune cells and a hostile microenvironment, present a significant hurdle in achieving robust antitumor responses. The open question lies in...
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