Pan-RAF:MEK Molecular Glues Take Center Stage

Hangauer, Matthew J.; Gutkind, Jorge Silvio; Ferguson, Fleur M.

doi:10.1158/2159-8290.CD-24-0539

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In the Spotlight| July 01 2024

Pan-RAF:MEK Molecular Glues Take Center Stage

Matthew J. Hangauer

0000-0002-5008-6696

;

Matthew J. Hangauer

1

Department of Dermatology, University of California San Diego, La Jolla, California.

3

UCSD Moores Cancer Center, University of California San Diego, La Jolla, California.

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Jorge Silvio Gutkind

0000-0002-5150-4482

;

Jorge Silvio Gutkind

2

Department of Pharmacology, University of California San Diego, La Jolla, California.

3

UCSD Moores Cancer Center, University of California San Diego, La Jolla, California.

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Fleur M. Ferguson

0000-0003-4091-7617

Fleur M. Ferguson *

3

UCSD Moores Cancer Center, University of California San Diego, La Jolla, California.

4

Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California.

5

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California.

*Corresponding Author: Fleur M. Ferguson, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093. E-mail: [email protected]

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Author & Article Information

*Corresponding Author: Fleur M. Ferguson, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093. E-mail: [email protected]

Cancer Discov 2024;14:1143–44

Received: April 30 2024

Accepted: May 01 2024

Online ISSN: 2159-8290

Print ISSN: 2159-8274

2024

American Association for Cancer Research

Cancer Discov (2024) 14 (7): 1143–1144.

https://doi.org/10.1158/2159-8290.CD-24-0539

Summary:

In this issue, Ryan and colleagues describe the preclinical development of a pan-RAF:MEK molecular glue with superior efficacy, brain penetrance, and tolerability in xenograft models of Ras/Raf/MAPK pathway–driven tumors.

2024

American Association for Cancer Research

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