Targeting the DHX9 RNA Helicase to Induce Antitumor Immunity in Small-Cell Lung Cancer

Chiappinelli, Katherine B.

doi:10.1158/2159-8290.CD-23-1523

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In the Spotlight| March 01 2024

Targeting the DHX9 RNA Helicase to Induce Antitumor Immunity in Small-Cell Lung Cancer

Katherine B. Chiappinelli

0000-0001-9241-9105

Katherine B. Chiappinelli *

1Department of Microbiology, Immunology, & Tropical Medicine, The George Washington University, Washington D.C.

2The GW Cancer Center, The George Washington University, Washington, D.C.

*Corresponding Author: Katherine B. Chiappinelli, Department of Microbiology, Immunology, & Tropical Medicine, George Washington University, 800 22nd Street, NW, Washington, DC, 20052, United States. E-mail: [email protected]

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Author & Article Information

*Corresponding Author: Katherine B. Chiappinelli, Department of Microbiology, Immunology, & Tropical Medicine, George Washington University, 800 22nd Street, NW, Washington, DC, 20052, United States. E-mail: [email protected]

Cancer Discov 2024;14:389–91

Online ISSN: 2159-8290

Print ISSN: 2159-8274

2024

American Association for Cancer Research

Cancer Discov (2024) 14 (3): 389–391.

https://doi.org/10.1158/2159-8290.CD-23-1523

Summary:

Murayama and colleagues establish DHX9 as an exciting new target to induce viral mimicry and downstream antitumor immunity. The potential for use in combination with existing immune therapies is especially exciting in SCLC, an immunologically cold and deadly disease.

2024

American Association for Cancer Research

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Targeting the DHX9 RNA Helicase to Induce Antitumor Immunity in Small-Cell Lung Cancer

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