Building an Organ-Wide Macroscopic View of Cancer Hallmarks

Liu, Suling; Wang, Yuan; Feng, Jiawen; Liu, Zhihua; Zhou, Shengtao

doi:10.1158/2159-8290.CD-24-0833

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Special Commentaries| November 01 2024

Building an Organ-Wide Macroscopic View of Cancer Hallmarks

Suling Liu

0000-0002-0475-0242

;

Suling Liu * ^#

1State Key Laboratory of Genetic Engineering, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Cancer Institutes, Shanghai, China.

*Corresponding Authors: Suling Liu, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, 270 DongAn Road, Building II, Room 1313B, Shanghai 200032, China. E-mail: [email protected]; Zhihua Liu, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Beijing 100006, China. E-mail: [email protected]; and Shengtao Zhou, Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, #20, the Third Section, Renmin South Road, Chengdu 610041, China. E-mail: [email protected]

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Yuan Wang

0000-0002-6324-6134

;

Yuan Wang ^#

2Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

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Jiawen Feng

0000-0001-6303-8338

;

Jiawen Feng ^#

3Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Institute of Systems Biomedicine, Peking University Health Science Center, Beijing, China.

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Zhihua Liu

0000-0003-4242-033X

;

Zhihua Liu *

4State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

*Corresponding Authors: Suling Liu, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, 270 DongAn Road, Building II, Room 1313B, Shanghai 200032, China. E-mail: [email protected]; Zhihua Liu, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Beijing 100006, China. E-mail: [email protected]; and Shengtao Zhou, Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, #20, the Third Section, Renmin South Road, Chengdu 610041, China. E-mail: [email protected]

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Shengtao Zhou

0000-0001-8322-5536

Shengtao Zhou *

5Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.

*Corresponding Authors: Suling Liu, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, 270 DongAn Road, Building II, Room 1313B, Shanghai 200032, China. E-mail: [email protected]; Zhihua Liu, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Beijing 100006, China. E-mail: [email protected]; and Shengtao Zhou, Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, #20, the Third Section, Renmin South Road, Chengdu 610041, China. E-mail: [email protected]

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Author & Article Information

*Corresponding Authors: Suling Liu, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, 270 DongAn Road, Building II, Room 1313B, Shanghai 200032, China. E-mail: [email protected]; Zhihua Liu, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dongdan Santiao, Beijing 100006, China. E-mail: [email protected]; and Shengtao Zhou, Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, #20, the Third Section, Renmin South Road, Chengdu 610041, China. E-mail: [email protected]

Cancer Discov 2024;14:2041–6

#

S. Liu, Y. Wang, and J. Feng contributed equally to this article.

Received: July 24 2024

Revision Received: August 23 2024

Accepted: August 26 2024

Online ISSN: 2159-8290

Print ISSN: 2159-8274

2024

American Association for Cancer Research

Cancer Discov (2024) 14 (11): 2041–2046.

https://doi.org/10.1158/2159-8290.CD-24-0833

Summary:

Despite an increasingly detailed understanding of cancer hallmarks at molecular or atomic resolution, most studies, however, fall short of investigating the systemic interactions of cancer with the human body. We propose to investigate the hallmarks of cancer from an organ-wide macroscopic view, discuss the challenges in preclinical and clinical research to study the cross-organ regulation of cancer together with potential directions to overcome these challenges, and foresee how this holistic view may be translated into more effective therapies.

2024

American Association for Cancer Research

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