Drugs Halt Replication Later than Thought Available to Purchase

The use of CDK4/6 inhibitors, such as palbociclib, has shown promise in treating breast cancer. Data suggest these drugs reverse cell replication farther along in the cell cycle than previously thought—with expanded clinical benefits. Yet, more research is needed to prove that a CDK4/6 inhibitor plus chemotherapy provides irreversible cell senescence because unstable treated cells could replicate and increase risk of disease recurrence.