Coexisting Genomic Alterations in Risk Stratification of KRAS^G12C-Mutated Non–Small Cell Lung Cancer

Negrao and colleagues showed that coalterations in three genes—KEAP1, SMARCA4, and CDKN2A— correlated to poor clinical outcomes in patients with KRAS^G12C-mutated non–small cell lung cancer treated with sotorasib or adagrasib. Their study highlights how pooling high-resolution real-world genomic data with clinical outcomes can potentially facilitate risk-stratified precision therapies.

See related article by Negrao et al., p. 1556 (2).