Results from the phase III SPOTLIGHT trial show that the investigational mAb zolbetuximab plus chemotherapy improves progression-free survival and overall survival in patients newly diagnosed with claudin 18.2–positive, HER2-negative locally advanced inoperable or metastatic gastric or gastroesophageal junction cancer. The drug could become a standard treatment option for these patients.

©2023 American Association for Cancer Research
2023
American Association for Cancer Research
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