Re-“Formate” T-cell Antitumor Responses

Lin, Mei-Chun; Moller, Sofie Hedlund; Ho, Ping-Chih

doi:10.1158/2159-8290.CD-23-1059

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In the Spotlight| December 12 2023

Re-“Formate” T-cell Antitumor Responses

Mei-Chun Lin

0000-0003-1133-6741

;

Mei-Chun Lin

1Department of Oncology, University of Lausanne, Lausanne, Switzerland.

2Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

3Ludwig Institute of Cancer Research, University of Lausanne, Lausanne, Switzerland.

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Sofie Hedlund Moller

0000-0002-2268-4277

;

Sofie Hedlund Moller *

1Department of Oncology, University of Lausanne, Lausanne, Switzerland.

3Ludwig Institute of Cancer Research, University of Lausanne, Lausanne, Switzerland.

*Corresponding Authors: Sofie Hedlund Moller, Department of Fundamental Oncology, University of Lausanne, Ludwig Institute for Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. E-mail: [email protected]; and Ping-Chih Ho, Department of Fundamental Oncology, University of Lausanne, Ludwig Institute for Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. E-mail: [email protected]

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Ping-Chih Ho

0000-0003-3078-3774

Ping-Chih Ho *

1Department of Oncology, University of Lausanne, Lausanne, Switzerland.

3Ludwig Institute of Cancer Research, University of Lausanne, Lausanne, Switzerland.

*Corresponding Authors: Sofie Hedlund Moller, Department of Fundamental Oncology, University of Lausanne, Ludwig Institute for Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. E-mail: [email protected]; and Ping-Chih Ho, Department of Fundamental Oncology, University of Lausanne, Ludwig Institute for Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. E-mail: [email protected]

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Author & Article Information

*Corresponding Authors: Sofie Hedlund Moller, Department of Fundamental Oncology, University of Lausanne, Ludwig Institute for Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. E-mail: [email protected]; and Ping-Chih Ho, Department of Fundamental Oncology, University of Lausanne, Ludwig Institute for Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. E-mail: [email protected]

Cancer Discov 2023;13:2507–9

Online ISSN: 2159-8290

Print ISSN: 2159-8274

2023

American Association for Cancer Research

Cancer Discov (2023) 13 (12): 2507–2509.

https://doi.org/10.1158/2159-8290.CD-23-1059

Summary:

Rowe and colleagues discover that one-carbon (1C) metabolism rewiring occurs upon T-cell activation to support proliferation and cytolytic activity in CD8⁺ T cells and that supplementation of 1C donor formate rescues the dysfunctional T cells and their responsiveness to anti–PD-1 in selective tumor-infiltrated T-cell subsets. This finding represents an attractive strategy to overcome a metabolic vulnerability in the tumor microenvironment and improve the efficacy of immune checkpoint blockade.

2023

American Association for Cancer Research

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