Summary:
Dose-limiting toxicities are thought to temper the efficacy of single-agent 4-1BB agonists. To overcome this hurdle, in this issue of Cancer Discovery, Muik and colleagues report preclinical and clinical studies describing a first-in-class bispecific fusion protein targeting 4-1BB and PD-L1.
See related article by Muik et al., p. 1248 (9).
©2022 American Association for Cancer Research
2022
American Association for Cancer Research
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