The incidence and mortality of triple-negative breast cancer (TNBC) are significantly higher in women of sub-Saharan African descent, with previous evaluations of racial differences being heavily reliant on self-reported race in U.S. populations. Martini and colleagues performed RNA sequencing of an international cohort of African Americans and West and East Africans, resulting in the identification of 613 genes associated with African ancestry and >2,000 genes connected to regional African ancestry. Differences in normal breast tissue were observed in a portion of African-associated genes, and distinct immunologic patterns in patients of African descent were detected. Together, these results may explain differential clinical outcomes between race groups.

See article, p. 2530.

Genetic ancestry is an important biological determinant of cancer health disparities. Arora and colleagues show that, although typically inferred using genome-wide markers, genetic ancestry can be reliably inferred from clinical cancer gene panel sequencing data, in which a pan-cancer cohort...

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