Obesity is both a risk factor for the development of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC), and a prognostically protective factor for clinical outcomes. In this issue of Cancer Discovery, Tan and colleagues identify the tumor- and adipose-derived adipokine chemerin as a circulating mediator of ccRCC lipid metabolism and ferroptotic susceptibility that may clarify the paradoxical relationship between ccRCC and obesity.

See related article by Tan et al., p. 2072.

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