See article, p. 1661.

Despite the success of chimeric antigen receptor (CAR) T-cell therapies for some leukemias and lymphomas, CAR T-cell efficacy in most solid tumors has been limited, perhaps in part due to a lack of T cell–supportive cytokines. Because the cytokine GM-CSF is often abundant in solid tumors, Lange, Sand, and colleagues designed CAR T cells expressing a CAR including the α and β chains of the GM-CSF receptor along with the transmembrane and signaling domains of the α and β chains of the IL18 receptor to ensure CAR T-cell stimulation and persistence at tumor sites. These CAR T cells exhibited improved efficacy against solid tumors in vivo.

See article, p. 1672.

EGFR inhibitors have shown efficacy in many types of EGFR-mutant non–small cell lung cancer (NSCLC) subtypes, but because the ATP binding site of a common type of EGFR mutant harboring insertions in...

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