“Dependency Map” Bears Fruit for Childhood Cancers Available to Purchase

The first comprehensive catalog of genetic vulnerabilities in pediatric tumors has identified dozens of potential new therapeutic targets, mostly in genes not known to harbor activating mutations—many unique to childhood cancers. The findings, part of the Cancer Dependency Map Project, reveal that pediatric cancers, despite their lower mutational burden relative to adult tumors, harbor just as many genes that cancer cells rely upon for growth and survival.