Noted This Week

The FDA granted accelerated approval to tucatinib (Tukysa; Seagen) in combination with trastuzumab for certain cases of inoperable RAS wild-type, HER2-positive metastatic colorectal cancer based on results of a phase II trial. In 84 patients who had previously received chemotherapy and a VEGF mAb, the HER2 inhibitor duo yielded an overall response rate (ORR) of 38% and a duration of response (DOR) of 12.4 months. The most common side effects were diarrhea, nausea, vomiting, rash, and hepatotoxicity.

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