Noted This Week

The FDA approved azacitidine (Vidaza; Celgene) for children with newly diagnosed juvenile myelomonocytic leukemia. The decision was based on the AZA-JMML-001 trial, in which 18 patients received azacitidine prior to hematopoietic stem cell (HSC) transplantation. Three patients experienced clinical complete remission (CR) and six experienced clinical partial remission, with a median time to response of 1.2 months; 94% underwent HSC transplantation, with a median time to transplantation of 4.6 months.

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