Cancer Discovery | American Association for Cancer Research

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Current Issue

Volume 14,

Issue 9

1 September 2024

About the Journal

Cancer Discovery publishes high-impact articles featuring major advances in research and clinical trials. Topics span the spectrum of cancer research and medicine from the laboratory to the clinic to epidemiologic studies. The journal also publishes News and Research Watch sections.Read More About the Journal

Editors-in-Chief

Lewis C. Cantley
Luis A. Diaz

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Impact Factor

30.6

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Featured Articles

The Hallmarks of Precancer

Mary M. Stangis, et al.

The History of Chromosomal Instability in Genome-Doubled Tumors

Toby M. Baker, et al.

Iron-(Fe³⁺)-Dependent Reactivation of Telomerase Drives Colorectal Cancers

Raghuvaran Shanmugam, et al.

News

| September 10 2024

Drug Combo Better than Single Agent in EGFR, MET-Mutated NSCLC

Combination therapy with the EGFR inhibitor osimertinib and the MET tyrosine kinase inhibitor savolitinib significantly improves outcomes for patients with EGFR -mutant, MET -aberrant non–small cell lung cancer compared with osimertinib ...

Breaking

| September 10 2024

Mammogram Reports Must Now Specify Breast Density

Beginning today, the FDA requires all mammography facilities to tell patients whether they have dense breast tissue when conveying screening results. People with dense breasts have a higher risk of breast cancer, and dense breast tissue makes it ...

Research Watch

| September 10 2024

The Fanconi Anemia Pathway Mediates Chromothripsis and Resistance to Cancer Therapy

Major Finding: Fanconi anemia pathway activity drives genome rearrangements and ecDNA formation via chromothripsis. Concept: Recruitment of the SLX4–XPF–ERCC1 endonuclease complex by FANCI–FANCD2 induces chromosome shattering. Impact: ...