Cancer Discovery | American Association for Cancer Research

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Current Issue

Volume 14,

Issue 10

1 October 2024

About the Journal

Cancer Discovery publishes high-impact articles featuring major advances in research and clinical trials. Topics span the spectrum of cancer research and medicine from the laboratory to the clinic to epidemiologic studies. The journal also publishes News and Research Watch sections.Read More About the Journal

Editors-in-Chief

Lewis C. Cantley
Luis A. Diaz

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Impact Factor

30.6

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Featured Articles

The Epigenetic Hallmarks of Cancer

Manel Esteller; Mark A. Dawson; Cigall Kadoch; Feyruz V. Rassool; Peter A. Jones; Stephen B. Baylin

T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study

Justin F. Gainor, et al.

The N⁶-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma

Shiyan Wang, et al.

News

| October 11 2024

Protein Innovators Win Chemistry Nobel

Three scientists will share the Nobel Prize in Chemistry for creating computational tools that transformed protein structure prediction and design, accelerating cancer research and drug discovery. Demis Hassabis and John Jumper were awarded for ...

Breaking

| October 11 2024

Gene Therapy Causes Cancer in Some Children

Seven out of the 67 children who received a gene therapy for a devastating neurologic disorder developed blood cancer ( N Engl J Med 2024 Oct 9 [Epub ahead of print] ). The therapy, elivaldogene autotemcel (Skysona; Bluebird Bio), consists of stem ...

Research Watch

| October 10 2024

Epigenetic Modification of Centromeric RNA Supports Genomic Stability

Major Finding: m 6 A modification of centromeric RNA (cenRNA) mediates CENPA binding and promotes cancer genomic stability. Concept: Leu61 and Arg63 of CENPA interact with m 6 A-modified cenRNA to support cancer cell proliferation. Impact: ...

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The article titled, Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis, has an Alt Metric Attention Score of 59.85. Click to see more of this article's metrics.

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Last mentioned on Saturday October 12 2024

The article titled, SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma, has an Alt Metric Attention Score of 13.6. Click to see more of this article's metrics.

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Last mentioned on Sunday October 13 2024

The article titled, Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer., has an Alt Metric Attention Score of 15.25. Click to see more of this article's metrics.

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Last mentioned on Saturday October 12 2024

The article titled, Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma, has an Alt Metric Attention Score of 136.72. Click to see more of this article's metrics.

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Last mentioned on Saturday October 12 2024

The article titled, TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells., has an Alt Metric Attention Score of 121.59. Click to see more of this article's metrics.

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Last mentioned on Saturday October 12 2024

Latest
Most Read
Most Cited

A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention

The Evolutionary Forest of Pancreatic Cancer

Glioblastoma-cortical organoids recapitulate cell state heterogeneity and intercellular transfer

MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer

About the Journal

Editors-in-Chief

Impact Factor

Featured Articles

The Epigenetic Hallmarks of Cancer

T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study

The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma

Trending - Altmetric

AACR Journals

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The N⁶-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma