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Research Brief

The KarMMa trial led to approval of idecabtagene vicleucel for relapsed/refractory multiple myeloma. This study determines the prognostic significance of serological and MRD responses in the KarMMa trial, pioneering prognostication of CAR T responses in myeloma.

Research Articles

The HBZ viral oncogene expressed in HTLV-1–infected T cells upregulates TAp73 by both RNA and protein forms, modulating lactate metabolism and epigenetic status to accelerate oncogenesis of adult T-cell leukemia/lymphoma.

A comprehensive single cell taxonomy of human bone marrow in healthy donors and acute myeloid leukemia patients identifies stromal niche remodeling as a candidate determinant of bone marrow failure and outcome in human AML.

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