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In the Spotlight

Research Articles

Diverse RNA-binding protein dependencies are identified for AML leukemic stem cells (LSC). Inhibition of ELAVL1 impairs splicing and RNA stabilization that supports LSC mitochondrial metabolism, identifying a novel therapeutic vulnerability.

Whole-genome sequencing of Hodgkin lymphoma identifies driver events and reconstructs their acquisition timing during B-cell ontogenesis and oncogenesis.

METTL3 regulates RNA splicing dysregulation to contribute to aggressive CLL via m6A modification-dependent translational control of splicing factors.

Expression of Concern

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