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Research Briefs

Triple-vaccinated myeloma patients lack CD8 responses and display suboptimal antibody responses, particularly against newer SARS-CoV-2 variants. Live-virus neutralization activity, rather than antibody titers, correlate with breakthrough infections.

A Phase I trial of early-line anti-BCMA and anti-CD19 CAR T cells in high-risk multiple myeloma patients demonstrated safety and feasibility of dual-target CAR T therapy with maintenance as an early-line treatment.

Research Articles

Comprehensive genomics reveal high prevalence of low hypodiploidy in older patients with B-ALL and track its origin to TP53-deficient age-associated clonal hematopoiesis.

A multiplex-edited mouse model of Richter syndrome transformation from CLL reveals dysregulated signaling pathways and potential therapeutic targets.

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