In This Issue
In the Spotlight
In Vivo Monitoring of Polycythemia Vera Development Reveals Carbonic Anhydrase 1 as a Potent Therapeutic Target
A focal model of PV development reveals its invasion of distant organ sites, dependency on the spleen, and carbonic anhydrase 1 as a potential therapy target.
Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms
Loss of Ca2+ binding causes ER stress and creates a unique dependency on the IRE1α/XBP1 pathway in type I and not type II mutant CALR-driven MPNs
Distinct Patterns of Clonal Evolution Drive Myelodysplastic Syndrome Progression to Secondary Acute Myeloid Leukemia
Multimodal single-cell profiling reveals clonal architecture and genetic drivers in the progression of MDS to AML.
Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression
Somatic signaling gene mutations occur frequently in MDS and undergo complex patterns of clonal evolution during progression to secondary AML. The presence of these mutations at MDS is associated with an increased risk of AML progression.
The Cell Type–Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia
Genome-wide landscape of 5hmC and cellular phenotypes in human hematopoiesis uncover epigenetic programs governing expansion of TET2-mutant clones, which can be countered by Vitamin C and azacitidine, offering insights into the mechanisms of TET-dependent clonal hematopoiesis.