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1 July 2020
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The labs of John Dick, Roland Kuiper, Charles Mullighan join forces to characterize mechanisms of relapse in a large cohort of pediatric ALL through the power of high-resolution genomics. They report that in most cases, relapse-associated mutations can be traced to a subclone already present at diagnosis. Taken from treatment-naïve patients, these subclones display drug resistance in mouse xenografts. The relapse-fated subclones carry genomic alterations known to drive resistance, and expand in patients following therapy. Clones persisting through serial relapses display hypermutation suggestive of increased immunogenicity. Genomic patterns revealed in this analysis may help identifying personalized therapies least prone to relapse. For details, please see the article by Waanders and colleagues on page 96 and a joint publication in the April issue of Cancer Discovery.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 2643-3230
EISSN 2643-3249
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Research Articles
Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions
Giovannino Silvestri; Rossana Trotta; Lorenzo Stramucci; Justin J. Ellis; Jason G. Harb; Paolo Neviani; Shuzhen Wang; Ann-Kathrin Eisfeld; Christopher J. Walker; Bin Zhang; Klara Srutova; Carlo Gambacorti-Passerini; Gabriel Pineda; Catriona H. M. Jamieson; Fabio Stagno; Paolo Vigneri; Georgios Nteliopoulos; Philippa C. May; Alistair G. Reid; Ramiro Garzon; Denis-Claude Roy; Moutuaata M. Moutuou; Martin Guimond; Peter Hokland; Michael W. Deininger; Garrett Fitzgerald; Christopher Harman; Francesco Dazzi; Dragana Milojkovic; Jane F. Apperley; Guido Marcucci; Jianfei Qi; Katerina Machova Polakova; Ying Zou; Xiaoxuan Fan; Maria R. Baer; Bruno Calabretta; Danilo Perrotti
Monosomic Loss of MIR15A/MIR16-1 Is a Driver of Multiple Myeloma Proliferation and Disease Progression
Marta Chesi; Caleb K. Stein; Victoria M. Garbitt; Meaghen E. Sharik; Yan W. Asmann; Matteo Bergsagel; Daniel L. Riggs; Seth J. Welsh; Erin W. Meermeier; Shaji K. Kumar; Esteban Braggio; P. Leif Bergsagel
Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia
Shinobu Tsuzuki; Takahiko Yasuda; Shinya Kojima; Masahito Kawazu; Koshi Akahane; Takeshi Inukai; Masue Imaizumi; Takanobu Morishita; Koichi Miyamura; Toshihide Ueno; Sivasundaram Karnan; Akinobu Ota; Toshinori Hyodo; Hiroyuki Konishi; Masashi Sanada; Hirokazu Nagai; Keizo Horibe; Akihiro Tomita; Kyogo Suzuki; Hideki Muramatsu; Yoshiyuki Takahashi; Yasushi Miyazaki; Itaru Matsumura; Hitoshi Kiyoi; Yoshitaka Hosokawa; Hiroyuki Mano; Fumihiko Hayakawa
Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia
Esmé Waanders; Zhaohui Gu; Stephanie M. Dobson; Željko Antić; Jeremy Chase Crawford; Xiaotu Ma; Michael N. Edmonson; Debbie Payne-Turner; Maartje van de Vorst; Marjolijn C.J. Jongmans; Irina McGuire; Xin Zhou; Jian Wang; Lei Shi; Stanley Pounds; Deqing Pei; Cheng Cheng; Guangchun Song; Yiping Fan; Ying Shao; Michael Rusch; Kelly McCastlain; Jiangyan Yu; Ruben van Boxtel; Francis Blokzijl; Ilaria Iacobucci; Kathryn G. Roberts; Ji Wen; Gang Wu; Jing Ma; John Easton; Geoffrey Neale; Scott R. Olsen; Kim E. Nichols; Ching-Hon Pui; Jinghui Zhang; William E. Evans; Mary V. Relling; Jun J. Yang; Paul G. Thomas; John E. Dick; Roland P. Kuiper; Charles G. Mullighan
Genomic Characterization of HIV-Associated Plasmablastic Lymphoma Identifies Pervasive Mutations in the JAK–STAT Pathway
Zhaoqi Liu; Ioan Filip; Karen Gomez; Dewaldt Engelbrecht; Shabnum Meer; Pooja N. Lalloo; Pareen Patel; Yvonne Perner; Junfei Zhao; Jiguang Wang; Laura Pasqualucci; Raul Rabadan; Pascale Willem
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