In This Issue
Science in Society
In the Spotlight
IVIg Use Associated with Ten-Fold Reduction of Serious Infections in Multiple Myeloma Patients Treated with Anti-BCMA Bispecific Antibodies
Multiple myeloma patients treated with anti-BCMA bispecific antibodies develop profound hypogammaglobulinemia and susceptibility to infections. Immunoglobulin replacement mitigates the risk of serious infections.
Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy
Ex vivo screening of primary AML samples for susceptibility to venetoclax-based drug combinations identify potentially effective combinations and patient characteristics associated with response.
Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells
A mass spectrometry–based immunopeptidomics characterizes the antigenic landscape of primary leukemic stem and progenitor cells in acute myeloid leukemia, identifying prime targets for the development of T cell–based immunotherapies targeting leukemia-repopulating cells.