Outcomes for patients with acute myeloid leukemia (AML) remain poor in part due to the inability of current therapeutic regimens to fully eradicate disease initiating leukemia stem cells (LSCs). We and others have shown that LSCs have unique and targetable metabolic vulnerabilities that can be exploited to induce apoptosis and kill this essential cell population. Interestingly the metabolic vulnerabilities that exist in LSCs appear to be highly dependent on the stage of disease pathogenesis, mutation status, and cellular state, suggesting that accounting for multiple biological factors is required when targeting metabolism in AML.

Citation Format: Courtney Jones. Inducing apoptosis in leukemia stem cells by targeting metabolism [abstract]. In: Proceedings of the AACR Special Conference: Acute Myeloid Leukemia and Myelodysplastic Syndrome; 2023 Jan 23-25; Austin, TX. Philadelphia (PA): AACR; Blood Cancer Discov 2023;4(3_Suppl):Abstract nr IA03.