In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttranslationally modified by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine–hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development.
An MYC-Driven Vicious Circuit Is a Targetable Achilles’ Heel in Lymphoma
Blood Cancer Discov 2023;4:248–51
Erica B. Wilson, Ulf Klein; An MYC-Driven Vicious Circuit Is a Targetable Achilles’ Heel in Lymphoma. Blood Cancer Discov 1 July 2023; 4 (4): 248–251. https://doi.org/10.1158/2643-3230.BCD-23-0053
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