Rise of the Clones: Myelodysplastic Syndrome to Secondary Acute Myeloid Leukemia

Myelodysplastic syndrome (MDS) describes a family of blood disorders driven by the clonal expansion of mutated blood cells that can evolve into secondary acute myeloid leukemia (sAML). Two new studies use single-cell and deep sequencing to elucidate the progression of MDS to AML, revealing discrete clonal architectures and the driving role of signaling mutations.

See related article by Guess et al., p. 316 (8).

See related article by Menssen et al., p. 330 (9).