Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFNγ Signaling to Gain Clonal Advantage

De Dominici, Marco; DeGregori, James

doi:10.1158/2643-3230.BCD-22-0025

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In the Spotlight| May 05 2022

Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFNγ Signaling to Gain Clonal Advantage

Marco De Dominici;

Marco De Dominici

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James DeGregori

James DeGregori *

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

*Corresponding Author: James DeGregori, University of Colorado Anschutz Medical Campus, Mail Stop 8101, P.O. Box 6511, 12801 East 17th Avenue, Aurora, CO 80045. Phone: 303-724-3230; E-mail: [email protected]

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Author & Article Information

*Corresponding Author: James DeGregori, University of Colorado Anschutz Medical Campus, Mail Stop 8101, P.O. Box 6511, 12801 East 17th Avenue, Aurora, CO 80045. Phone: 303-724-3230; E-mail: [email protected]

Blood Cancer Discov 2022;3:178–80

Online ISSN: 2643-3249

Print ISSN: 2643-3230

2022

American Association for Cancer Research

Blood Cancer Discov (2022) 3 (3): 178–180.

https://doi.org/10.1158/2643-3230.BCD-22-0025

Summary:

Dnmt3a-mutant stem cells gain a competitive advantage via upregulation of a Txnip–p53–p21 axis and protection from IFNγ induced exhaustion.

See related article by Zhang et al., p. 220 (5).

2022

American Association for Cancer Research

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Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFNγ Signaling to Gain Clonal Advantage

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Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFNγ Signaling to Gain Clonal Advantage