Comparatively no phase of the cancer problem has received less attention in the last decade than the cytological phenomena of cancer cells in division. Obviously, this deserves more attention. According to our present knowledge, cancer is directly bound up with the process of nuclear and cell division. Without cell division, there is no cancer. The essence of the problem concerns the growth, development, and reproduction of the so-called cancer cell. The entire cancer problem disappears with the failure of nuclei and cells to divide.

A report is made in the present paper, as detailed as space will permit, on a number of cellular studies in human and animal cancer, together with the overgrowths in plants commonly known as crown gall. Only such phases of the problem are dealt with as will throw light on the nuclear and cytoplasmic behavior in cell division in neoplastic tissues. The various cytoplasmic constituents, such as mitochondria and the Golgi apparatus, have been given little attention.

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