Introduction

In a previous paper (1) it was shown that the development of small malignant tumors in animals was completely inhibited by repeated intratumoral injections of suprarenalin, but that repeated subcutaneous injections of suprarenalin at a point distant from the tumor failed to show any inhibiting influence upon the growth of carcinoma and sarcoma. Hence it appears probable that the destructive action which suprarenalin exerts upon the tumor is due to its marked vasoconstrictive power.

In this paper we wish to present the results of experiments designed to determine the influence of various extracts of suprarenal cortex on the development of transplanted tumors in rats, mice, and chickens.

Preparation of Suprarenal Cortical Extracts

The following general technic was employed in order to obtain the mixtures and solutions of suprarenal cortex. Suprarenal glands of young sheep or cattle were brought from the abattoir, packed in ice, within one hour after the death of the animals. The cortex was dissected as free as possible from extraneous fats and medullary tissue. This was conveniently done by cutting a suprarenal gland into four pieces lengthwise and then removing the medullary tissue with small scissors. During these operations the suprarenal glands, as well as the cortices, were kept cold by placing the beakers containing them on chopped ice.

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