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The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand–dependent Cancer Models
Caroline Phillips; Inder Bhamra; Catherine Eagle; Eimear Flanagan; Richard Armer; Clifford D. Jones; Matilda Bingham; Peter Calcraft; Alicia Edmenson Cook; Ben Thompson; Simon A. Woodcock
ZL-1211 Exhibits Robust Antitumor Activity by Enhancing ADCC and Activating NK Cell–mediated Inflammation in CLDN18.2-High and -Low Expressing Gastric Cancer Models
Hiroyasu Konno; Tracey Lin; Renyi Wu; Xinchuan Dai; Shou Li; Grace Wang; Min Chen; Wenying Li; Lina Wang; Bee-Chun Sun; Zhen Luo; Tom Huang; Yuping Chen; John Zhang; Qiuping Ye; David Bellovin; Bing Wan; Lishan Kang; Christopher Szeto; Karl Hsu; Omar Kabbarah
A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice
Natalia E. Cortez; Cecilia Rodriguez Lanzi; Brian V. Hong; Jihao Xu; Fangyi Wang; Shuai Chen; Jon J. Ramsey; Matthew G. Pontifex; Michael Müller; David Vauzour; Payam Vahmani; Chang-il Hwang; Karen Matsukuma; Gerardo G. Mackenzie
SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma Progression
Mariafausta Fischietti; Frank Eckerdt; Ricardo E. Perez; Jamie N. Guillen Magaña; Candice Mazewski; Sang Ho; Christopher Gonzalez; Lukas D. Streich; Elspeth M. Beauchamp; Amy B. Heimberger; Aneta H. Baran; Feng Yue; C. David James; Leonidas C. Platanias
Bintrafusp Alfa, an Anti-PD-L1:TGFβ Trap Fusion Protein, in Patients with ctDNA-positive, Liver-limited Metastatic Colorectal Cancer
Van K. Morris; Michael J. Overman; Michael Lam; Christine M. Parseghian; Benny Johnson; Arvind Dasari; Kanwal Raghav; Bryan K. Kee; Ryan Huey; Robert A. Wolff; John Paul Shen; June Li; Isabel Zorrilla; Ching-Wei D. Tzeng; Hop S. Tran Cao; Yun Shin Chun; Timothy E. Newhook; Nicolas Vauthey; Dzifa Duose; Raja Luthra; Cara Haymaker; Scott Kopetz
Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Ryan M. Murphy; Jason Tasoulas; Alessandro Porrello; Miranda B. Carper; Yi-Hsuan Tsai; Alisha R. Coffey; Sunil Kumar; Peter YF. Zeng; Travis P. Schrank; Bentley R. Midkiff; Stephanie Cohen; Ashley H. Salazar; Michele C. Hayward; D. Neil Hayes; Andrew Olshan; Gaorav P. Gupta; Anthony C. Nichols; Wendell G. Yarbrough; Chad V. Pecot; Antonio L. Amelio
Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry
Jason A. White; Ernest T. Kaninjing; Kayode A. Adeniji; Paul Jibrin; John O. Obafunwa; Chidiebere N. Ogo; Faruk Mohammed; Ademola Popoola; Omolara A. Fatiregun; Olabode P. Oluwole; Balasubramanyam Karanam; Isra Elhussin; Stefan Ambs; Wei Tang; Melissa Davis; Paz Polak; Moray J. Campbell; Kathryn R. Brignole; Solomon O. Rotimi; Windy Dean-Colomb; Folake T. Odedina; Damali N. Martin; Clayton Yates
NetrinG1+ Cancer-Associated Fibroblasts Generate Unique Extracellular Vesicles that Support the Survival of Pancreatic Cancer Cells Under Nutritional Stress
Kristopher S. Raghavan; Ralph Francescone; Janusz Franco-Barraza; Jaye C. Gardiner; Débora B. Vendramini-Costa; Tiffany Luong; Narges Pourmandi; Anthony Andren; Alison Kurimchak; Charline Ogier; Paul M. Campbell; James S. Duncan; Costas A. Lyssiotis; Lucia R. Languino; Edna Cukierman
Real-world Validation of TMB and Microsatellite Instability as Predictive Biomarkers of Immune Checkpoint Inhibitor Effectiveness in Advanced Gastroesophageal Cancer
Ryon P. Graf; Virginia Fisher; James Creeden; Alexa B. Schrock; Jeffrey S. Ross; Halla Nimeiri; Geoffrey R. Oxnard; Samuel J. Klempner
Pathway-based Approach Reveals Differential Sensitivity to E2F1 Inhibition in Glioblastoma
Alvaro G. Alvarado; Kaleab Tessema; Sree Deepthi Muthukrishnan; Mackenzie Sober; Riki Kawaguchi; Dan R. Laks; Aparna Bhaduri; Vivek Swarup; David A. Nathanson; Daniel H. Geschwind; Steven A. Goldman; Harley I. Kornblum
Pharmacologic Inhibition of SHP2 Blocks Both PI3K and MEK Signaling in Low-epiregulin HNSCC via GAB1
Richard Kurupi; Konstantinos V. Floros; Sheeba Jacob; Ayesha T. Chawla; Jinyang Cai; Bin Hu; Madhavi Puchalapalli; Colin M. Coon; Rishabh Khatri; Giovanna Stein Crowther; Regina K. Egan; Ellen Murchie; Patricia Greninger; Krista M. Dalton; Maninderjit S. Ghotra; Sosipatros A. Boikos; Jennifer E. Koblinski; Hisashi Harada; Yue Sun; Iain M. Morgan; Devraj Basu; Mikhail G. Dozmorov; Cyril H. Benes; Anthony C. Faber
The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
Katrine Ingelshed; Diana Spiegelberg; Pavitra Kannan; Linnéa Påvénius; Jessica Hacheney; Long Jiang; Silke Eisinger; Danai Lianoudaki; Dilraj Lama; Francisca Castillo; Cecilia Bosdotter; Warren W. Kretzschmar; Omayma Al-Radi; Nicolas Fritz; Eduardo J. Villablanca; Mikael C. I. Karlsson; Fredrik Wermeling; Marika Nestor; David P. Lane; Saikiran K. Sedimbi
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