Mouse Models Collection
The AACR editors are proud to present this selection of impactful journal articles featuring mouse models, published from across the AACR journal portfolio.
Inflammation-related IL-1β/IL-1R signaling promotes the development of asbestos-induced malignant mesothelioma.
Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJP, Pietrofesa RA, et al. Cancer Prevention Research 2016; DOI: 10.1158/1940–6207.CAPR–15–0347. [Published OnlineFirst March 2, 2016].
SOX4 is essential for prostate tumorigenesis initiated by PTEN ablation.
Bilir B, Osunkoya AO, Wiles WG, Sannigrahi S, Lefebvre, Metzger D, et al. Cancer Research 2016;76:1112–21.
Bap1 is a bona fide tumor suppressor: genetic evidence from mouse models carrying heterozygous germline Bap1 mutations.
Kadariya Y, Cheung M, Xu J, Pei J, Sementino E, Menges CW, et al. Cancer Research 2016; DOI: 10.1158/0008–5472.CAN–15–3371. [Published OnlineFirst February 19, 2016].
STAT5 is a key regulator in NK cells and acts as molecular switch from tumor surveillance to tumor promotion.
Gotthardt D, Putz EM, Grundschober E, Prchal-Murphy M, Straka E, Kudweis P, et al. Cancer Discovery 2016; DOI: 10.1158/2159–8290.CD–15–0732. [Published OnlineFirst February 12, 2016].
GSK-3β governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression.
Baumgart S, Chen NM, Zhang JS, Billadeau DD, Gaisina IN, Kozikowski AP, et al. Molecular Cancer Therapeutics 2016;15:491–502.
Inhibition of Akt enhances the chemopreventive effects of topical rapamycin in mouse skin.
Dickinson SE, Janda J, Criswell J, Blohm-Mangone K, Olson ER, Liu Z, et al. Cancer Prevention Research 2016;9:215–24.
Proteomic characterization of head and neck cancer patient–derived xenografts.
Li H, Wheeler S, Park Y, Ju Z, Thomas SM, Fichera M, et al. Molecular Cancer Research 2016;14:278–86.
Comparing patient-derived xenograft and computational response prediction for targeted therapy in patients of early-stage large cell lung cancer.
Li J, Ye C, Mansmann UR. Clinical Cancer Research 2015; DOI: 10.1158/1078-0432.CCR–15–2401. [Published OnlineFirst December 4, 2015].
Defining ATM-independent functions of the Mre11 complex with a novel mouse model.
Balestrini A, Nicolas L, Yang-lott K, Guryanova OA, Levine RL, Bassing CH, et al. Molecular Cancer Research 2016;14:185–95.
Aurora A is critical for survival in HPV-transformed cervical cancer.
Gabrielli B, Bokhari F, Ranall MV, Oo ZY, Stevenson AJ, Wang W, et al. Molecular Cancer Therapeutics 2015;14:2753–61.
NKTR-214, an engineered cytokine with biased IL2 receptor binding, increased tumor exposure, and marked efficacy in mouse tumor models .
Charych DH, Hoch U, Langowski JL, Lee SR, Addepalli MK, Kirk PB, et al. Clinical Cancer Research 2016;22:680–90.
Dual roles of RNF2 in melanoma progression.
Rai K, Akdemir KC, Kwong LN, Fiziev P, Wu CJ, Keung EZ, et al. Cancer Discovery 2015;5:1314–27.
Afatinib plus cetuximab delays resistance compared to single-agent erlotinib or afatinib in mouse models of TKI-naïve EGFR L858R-induced lung adenocarcinoma.
Pirazzoli V, Ayeni D, Meador CB, Sanganahalli BG, Hyder F, de Stanchina E, et al. Clinical Cancer Research 2016;22:426–35.
Vitamin D repletion reduces the progression of premalignant squamous lesions in the NTCU lung squamous cell carcinoma mouse model.
Mazzilli SA, Hershberger PA, Reid ME, Bogner PN, Atwood K, Trump DL, et al. Cancer Prevention Research 2015;8:895–904.