Metabolism and Cancer Collection
The AACR editors are proud to present this selection of impactful journal articles focusing on metabolism and cancer, published from across the AACR journal portfolio.
Clinical trial of 2-phenethyl isothiocyanate as an inhibitor of metabolic activation of a tobacco-specific lung carcinogen in cigarette smokers.
Hecht SS, Yuan JM, Stepanov I, Murphy SE, Wang R, Allen SS, et al. Cancer Prevention Research 2016; DOI:10.1158/1940-6207.CAPR-15-0380. [Published OnlineFirst March 7, 2016].
Impact of pre-analytic blood sample collection factors on metabolomics
Townsend MK, Bao Y, Poole EM, Bertrand KA, Kraft P, Wolpin BM, et al. Cancer Epidemiology, Biomarkers & Prevention 2016; DOI:10.1158/1055-9965.EPI-15-1206. [Published OnlineFirst March 3, 2016].
Molecular profile and FDG-PET/CT total metabolic tumor volume improve risk classification at diagnosis for patients with diffuse large B-cell lymphoma.
Cottereau AS, Lanic H, Mareschal S, Meignan M, Vera P, Tilly H, et al. Clinical Cancer Research 2016; DOI:10.1158/1078-0432.CCR-15-2825. [Published OnlineFirst March 2, 2016].
Regulatory T cells from colon cancer patients inhibit effector T-cell migration through an adenosine-dependent mechanism.
Sundström P, Stenstad H, Langenes V, Ahlmanner F, Theander L, Ndah TG, et al. Cancer Immunology Research 2016;4:183–93.
Metabolome analyses uncovered a novel inhibitory effect of acyclic retinoid on aberrant lipogenesis in a mouse diethylnitrosamine-induced hepatic tumorigenesis model.
Xian-Yang Qin, Tatsukawa H, Hitomi K, Shirakami Y, Ishibashi N, Shimizu M, et al. Cancer Prevention Research 2016;9:205–14.
MR studies of glioblastoma models treated with dual PI3K/mTOR inhibitor and temozolomide—metabolic changes are associated with enhanced survival
Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM. Molecular Cancer Therapeutics 2016; doi:10.1158/1535-7163.MCT-15-0769. [Published OnlineFirst February 16, 2016].
Mass spectrometry–based metabolomics identifies longitudinal urinary metabolite profiles predictive of radiation-induced cancer.
Cook JA, Chandramouli GVR, Anver MR, Sowers AL, Thetford A, Krausz KW, et al. Cancer Research 2016;76:1569–77.
The ephrin-A1/EPHA2 signaling axis regulates glutamine metabolism in HER2-positive breast cancer.
Youngblood VM, Kim LC, Edwards DN, Hwang Y, Santapuram PR, Stirdivant SM, et al. Cancer Research 2016; DOI:10.1158/0008-5472.CAN-15-0847. [Published OnlineFirst February 1, 2016].
The role of CD44 in glucose metabolism in prostatic small cell neuroendocrine carcinoma.
Li W, Cohen A, Sun Y, Squires J, Braas D, Graeber TG, et al. Molecular Cancer Research 2016; DOI:10.1158/1541-7786.MCR-15-0466. [Published OnlineFirst February 1, 2016].
Alternate metabolic programs define regional variation of relevant biological features in renal cell carcinoma progression.
Brooks SA, Khandani AH, Fielding JR, Lin W, Sills T, Lee Y, et al. Clinical Cancer Research 2016; DOI:10.1158/1078-0432.CCR-15-2115. [Published OnlineFirst January 19, 2016].
Detection of pancreatic cancer–induced cachexia using a fluorescent myoblast reporter system and analysis of metabolite abundance.
Winnard PT, Bharti SK, Penet MF, Marik R, Mironchik Y, Wildes F, et al. Cancer Research 2016;76:1441–50.
Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals: demographics, lifestyle, genetics, and toxicity.
Jansen RJ, Argos M, Tong L, Li J, Rakibuz-Zaman M, Islam MT, et al. Cancer Epidemiology, Biomarkers & Prevention 2016;25:381–90
Linking cancer metabolism to DNA repair and accelerated senescence.
Efimova EV, Takahashi S, Shamsi NA, Wu D, Labay E, Ulanovskaya OA, et al. Molecular Cancer Research 2016;14:173–84.
Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in myc-driven lymphoma.
Devlin JR, Hannan KM, Hein N, Cullinane C, Kusnadi E, Ng PY, et al. Cancer Discovery 2016;6:59–70.
A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics.
Sadanandam A, Wullschleger, Lyssiotis CA, Grötzinger C, Barbi S, Bersani S, et al. Cancer Discovery 2015;5:1296–313
Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies.
Hossain F, Al-Khami AA, Wyczechowska D, Hernandez C, Zheng L, Reiss K, et al. Cancer Immunology Research 2015;3:1236–47.