Colorectal Cancer Collection
The AACR editors are proud to present this selection of impactful journal articles focusing on colorectal cancer, published from across the AACR journal portfolio.
Distinct transcriptional changes and epithelial–stromal interactions are altered in earlystage colon cancer development.
Mo A, Jackson S, Varma K, Carpino A, Giardina C, Devers TJ, et al. Molecular Cancer Research 2016;14:795804.
Downregulation of the deiminase PADI2 is an early event in colorectal carcinogenesis and indicates poor prognosis.
Cantariño N, Musulén E, Valero V, Peinado MA, Perucho M, Moreno V, et al. Molecular Cancer Research 2016;14:841–8.
The firstinclass antiEGFR antibody mixture Sym004 overcomes cetuximabresistance mediated by EGFR extracellular domain mutations in colorectal cancer.
SanchezMartín FJ, Bellosillo B, Gelabert M, Dalmases A, Cañadas I, Vidal J, et al. Clinical Cancer Research 2016; DOI: 10.1158/1078–0432.CCR–15–2400. [Published OnlineFirst February 17, 2016].
Redundant innate and adaptive sources of IL17 production drive colon tumorigenesis.
Housseau F, Wu S, Wick EC, Fan W, Wu X, Llosa NJ, et al. Cancer Research 2016; DOI: 10.1158/0008–5472.CAN–15–0749. [Published OnlineFirst February 15, 2016].
Circulating DNA as a strong multimarker prognostic tool for metastatic colorectal cancer patient management care.
El Messaoudi S, Mouliere F, Du Manoir S, BascoulMollevi C, Gillet B, Nouaille M, et al. Clinical Cancer Research 2016; DOI: 10.1158/1078–0432.CCR–15–0297. [Published OnlineFirst February 4, 2016].
Inhibition of HSP90 by AUY922 preferentially kills mutant KRAS colon cancer cells by activating Bim through ER stress.
Wang CY, Guo ST, Wang JY, Liu F, Zhang YY, Yari H, et al. Molecular Cancer Therapeutics 2016; DOI: 10.1158/1535–7163.MCT–15–0778. [Published OnlineFirst February 1, 2016].
Germline genetic variants in the Wnt/βcatenin pathway as predictors of colorectal cancer risk.
Hildebrandt MAT, Reyes ME, Lin M, He Y, Nguyen SV, Hawk ET, et al. Cancer Epidemiology, Biomarkers & Prevention 2016; DOI: 10.1158/1055–9965.EPI–15–0834. [Published OnlineFirst January 25, 2016].
Obesityinduced colorectal cancer is driven by caloric silencing of the guanylin–GUCY2C paracrine signaling axis.
Lin EJ, ColonGonzalez F, Blomain E, Kim GW, Aing A, Stoecker B, et al. Cancer Research 2016;76:339–46.
Assessment of the in vivo activity of PI3K and MEK inhibitors in genetically defined models of colorectal cancer.
Raja M, Zverev M, Seipel K, Williams GT, Clarke AR, Shaw PHS. Molecular Cancer Therapeutics 2015;14:2175–86.
Serum endotoxins and flagellin and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Kong SY, Tran HQ, Gewirtz AT, McKeownEyssen G, Fedirko V, Romieu I, et al. Cancer Epidemiology, Biomarkers & Prevention 2016;25:291–301.
Identification of targetable kinase alterations in patients with colorectal carcinoma that are preferentially associated with wildtype RAS/RAF.
Hechtman JF, Zehir A, Yaeger R, Wang Lu, Middha S, Zheng T, et al. Molecular Cancer Research 2016;14:296–301.
Tumor heterogeneity and lesionspecific response to targeted therapy in colorectal cancer.
Russo M, Siravegna G, Blaszkowsky LS, Corti G, Crisafulli C, Ahronian LJ, et al. Cancer Discovery 2016;6:147–53.
Plasma inflammatory markers and risk of advanced colorectal adenoma in women.
Song M, Mehta RS, Wu K, Fuchs CS, Ogino S, Giovannucci EL, et al. Cancer Prevention Research 2016;9:27–34.
Colon tumors with the simultaneous induction of driver mutations in APC, KRAS, and PIK3CA still progress through the adenomatocarcinoma sequence.
Hadac JN, Leystra AA, Olson TJP, Maher ME, Payne SN, Yueh AE, et al. Cancer Prevention Research 2015;8:952–61.
Regulatory Tcell response to enterotoxigenic Bacteroides fragilis colonization triggers IL17dependent colon carcinogenesis.
Geis AL, Fan H, Wu Q, Wu S, Huso DL, Wolfe JL, et al. Cancer Discovery 2015;5:1098–109.
Loss of stromal IMP1 promotes a tumorigenic microenvironment in the colon.
Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, et al. Molecular Cancer Research 2015;13:1478–86.